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NSC 23766

CAS 733767-34-5

C24H35N7.3HCl  MW 530.97

Purity: 99%

Soluble in water (>100 mM) 

Ordering Information:

Cat. No. Axon 1578    Prime Souce Promotion 

Qty1: 10 mg / €125  $163

Qty1: 50 mg / €425  $553

Qty3: on request

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Biological Activity:   A cell-permeable, reversible, and selective Rac1 inhibitor; inhibiting Rac1 activation by the Rac-specific GEFs TrioN and Tiam 1 (IC50 = 50 μM) without affecting the closely related GTPases, Cdc42, and RhoA activation; a useful tool for studying the Rac-mediated cellular functions and for modulating pathological conditions in which Rac-deregulation may play a role.   References: online   M Vallon et al. Tumor endothelial marker 5 expression in endothelial cells during capillary morphogenesis is induced by the small GTPase Rac and mediates contact inhibition of cell proliferation. Exp. Cell Res. 2010, 316 412-421. [online]   EE Bosco et al. Rac1 GTPase: A “Rac” of all trades. Cell Mol. Life Sci. 2009, 66 370-374. [online]   J Wang et al. Overexpression of Rac1 in leukemia patients and its role in leukemia cell migration and growth. Biochem Biophys Res Commun 2009, 386 769-774. [online]   E Whitney et al. The Rac1 inhibitor, NSC23766, depolarizes adhesive secretion, endomembrane cycling, and tip growth in the fucoid alga, Silvetia compressa. PLANTA 2008, 227(5), 991-1000. [online]   JA Cancelas et al. Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. Nat. Med 2005, 11(8), 886-891. [online]   Y Gao et al. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci USA 2004, 101(20), 7618-7623. [online]     Chemical Name: N6-​[2-​[[4-​(diethylamino)-​1-​methylbutyl]amino]-​6-​methyl-​4-​pyrimidinyl]-​2-​methyl-​4,​6-​quinolinediamine​ trihydrochloride

NSC 23766 | Rac1-GEF inhibitor | Axon Medchem | Axon 1578 | NSC23766

Axon Ligands ^TM  - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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