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GW 803430 

GW 3430

CAS 515141-51-2

C25H24ClN3O3S  MW 481.99

Purity: 99%

Soluble in DMSO and 1 eq HCl (aq)

Ordering Information:

Cat. No. Axon 1569    Prime Source 

Qty1:  5 mg / €115  $150

Promotion: 2 x 5 mg @ €180  $234

Qty2: 25 mg / €385  $501

Promotion: 2 x 25 mg @ €580  $754

Qty3: on request

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Biological Activity:   Selective, non-peptide antagonist at the melanin concentrating hormone receptor 1 (MCH1 aka MCH R1). In animal studies it has anxiolytic, antidepressant and anorectic effects.   References: online DR Gehlert et al. Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression. J. Pharmacol. Exp. Ther. 2009, 329 (2), 429–438. [online]   SL Able et al. Localisation of melanin-concentrating hormone receptor 1 in rat brain and evidence that sleep parameters are not altered despite high central receptor occupancy. Eur. J. Pharmacol. 2009, 616(1-3), 101-106.   S Chaki and K Kanuma. Neuropeptide receptors: Novel therapeutic targets for depression and anxiety disorders. Drugs Fut. 2007, 32(9), 809.     Chemical Name: 6-(4-chlorophenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one

GW 803430 | MCH R1 antagonist | Axon Medchem | Axon 1569 | GW803430 - GW 3430 - GW3430

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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