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Biological Activity:
Tienilic acid was found to act as a suicide substrate at the cytochrome P450 enzymes involved in drug metabolism. It is a good mechanism based inhibitor of CYP2C9 and seems to inactivate it stoechiometrically.
References: online
JW Manier et al. Hepatotoxicity associated with ticrynafen – a uricosuric diuretic. Am. J. Gastroenterol. 1982, 77(6), 401–4.
P Jean et al. Oxidation of tienilic acid by human yeast-expressed cytochromes P450 2C8, 2C9, 2C18 and 2C19: Evidence that this drug is a mechanism-based inhibitor specific of cytochrome P450 2C9. Eur. J. Biochem. 1996, 241 797-804.
Chemical Name: [2,3-dichloro-4-(2-thienylcarbonyl)phenoxy]acetic acid
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