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Org 25935

SCH 900435

CAS 949588-40-3

C21H25NO3.HCl  MW 375.90

Purity: 99%

Ordering Information:

Cat. No. Axon 1563    Prime Source Promotion

Qty1: 5 mg (research sample) / €125  $163

Qty2: 25 mg (research sample) / €425  $553

Qty3: on request

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Biological Activity:   Potent and selective GlyT-1 glycine transporter or reuptake inhibitor; a therapeutic intended for the treatment of neurological disorders.   References:   HH Lidoe et al. The glycine reuptake inhibitor Org 25935 interacts with basal and ethanol-induced dopamine release in rat nucleus accumbens. Alcoholism: Clin. Exp. Res. 2009, 33(7), 1151-1157.   K Morita et al. Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice. J. Pharmacol. Exp. Ther. 2008, 326(2), 633-645.   A Molander et al. The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male Wistar rats. Alcohol and Alcoholism (Oxford, United Kingdom) (2007), 42(1), 11-18.   K Hashimoto. Glycine Transporter Inhibitors as Therapeutic Agents for Schizophrenia. Recent Patents on CNS Drug Discovery, 2006, 1, 43-53. [online]     Chemical Name: Glycine, N-methyl-N-[[(1R,2S)-1,2,3,4-tetrahydro-6-methoxy-1-phenyl-2-naphthalenyl]methyl]-, hydrochloride (1:1), rel-

Org 25935 | GlyT-1 inhibitor | Axon Medchem | Axon 1563 | Org25935 | Sch900435

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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