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TWS 119

CAS 601514-19-6

C18H14N4O2  MW 318.33

Purity: 99 %

Soluble in DMSO to 50 mM

Ordering Information:

Cat. No. Axon 1562     Prime Source

Qty1: 2 mg(research sample) / €95  $124

Qty2: 5 mg (research sample) / €135  $175 

Qty3: 25 mg (research sample) / €475  $618

Qty4: on request

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Biological Activity:   Potent and selective inhibitor of GSK-3 beta subtype (GSK-3β) (IC50: 30 nM); Neurogenesis inducer in murine ESC and thus a useful tool to regulate stem cell self-renewal and differentiation.   References:   Dessalew et al. Investigation of potential glycogen synthase kinase 3 inhibitors using pharmacophore mapping and virtual screening. Chem. Biol. Drug Design 2006, 68, 154-165   S Ding et al. Synthetic small molecules that control stem cell fate. PNAS USA. 2003, 100(13), 7632-7637.     Chemical Name: 3-[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy]phenol

TWS 119 | GSK-3β inhibitor | Axon Medchem | Axon 1562 | TWS119

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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