Axon Ligands (TM) - alphabetic: [A] [B] [C] [D] [E] [F] [G] [H] [I] [J] [K] [L] [M] [N] [O] [P] [Q] [R] [S] [T] [U] [V] [W] [X] [Y] [Z]

MK 0364  -  Taranabant

CAS 701977-09-5

C27H25ClF3N3O2 MW 515.95

Purity: 99% (optically pure)

Soluble in DMSO to 95 mM

Ordering Information:

Cat. No. Axon 1550     Prime Source

Qty1: 2 mg (research sample) / €105  $137

Qty2: 5 mg (research sample) / €165  $215

Qty3: on request contract research synthesis

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Contact us for our product range and services.

Biological Activity:   Potent and selective cannabinoid receptor type 1 (CB1) antagonist and/or inverse agonist   References: online   TM Fong et al. Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents. J. Pharmacol. Exp. Ther. 2007, 321(3), 1013-1022.   MS Kipnes et al. A one-year study to assess the safety and efficacy of the CB1R inverse agonist taranabant in overweight and obese patients with type 2 diabetes. Diabetes, Obesity & Metabolism 2010, 12 (6), 517–31.   Chemical Name: N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2- ((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide

MK 0364 - Taranabant | CB1 inverse agonist | Axon Medchem | Axon 1550 | MK0364 - MK 364 - MK364

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

axonmedchem.com © 2011

Axon Ligands In The Field: