Axon Ligands (TM) - alphabetic: [A] [B] [C] [D] [E] [F] [G] [H] [I] [J] [K] [L] [M] [N] [O] [P] [Q] [R] [S] [T] [U] [V] [W] [X] [Y] [Z]

SSR 504734

CAS 665571-23-8 (HCl)

742693-38-5 (parent)

C20H20ClF3N2O  MW 433.3

Purity: 99% (optically pure)

Ordering Information:

Cat. No. Axon 1549      Exclusive Promotion

Qty1: 2 mg (research sample) / €125  $163

Qty2: 5 mg (research sample) / €205  $267

Qty3: on request contract research synthesis

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Biological Activity:   A potent, selective and orally active GlyT-1 inhibitor, blocked the ex vivo uptake of glycine rapidly, reversibly, and for a long duration; exhibiting activity in animal models of schizophrenia, anxiety and depression.   References:   G Depoortere et al. Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic. Neuropsychopharmacology 2005, 30, 1963–1985. [online] K Hashimoto. Glycine Transporter Inhibitors as Therapeutic Agents for Schizophrenia. Recent Patents on CNS Drug Discovery, 2006, 1, 43-53. [online]     Chemical Name: 2-Chloro-N-[1(S)-phenyl-1-[2(S)-piperidinyl]methyl]-3-(trifluoromethyl)benzamide hydrochloride

SSR 504734 | GlyT-1 inhibitor | Axon Medchem | Axon 1549 | SSR504734

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Axon Ligands in the field:

ALX 5407 | GlyT-1 inhibitor

Org 25935 | GlyT-1 inhibitor

SSR 504734 | GlyT-1 inhibitor

Axon Ligands ^TM    

Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.