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AZ 628

CAS 878739-06-1 

C27H25N5O2

MW 451.53 

Purity: 99%

Soluble in DMSO 

Ordering Information:

Cat. No. Axon 1545     Prime Source

Qty1: 5 mg (research sample) / €135  $176

Promotion: 2 x 5 mg @ €180  $234

Qty2: 25 mg (research sample) / €405  $527

Promotion: 2 x 25 mg @ €600  $780

Qty3: on request contract research synthesis

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Biological Activity:   Selective RAF inhibitor, showing strong selectivity for RAF kinases among a panel of 150 tested kinases; IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF.   References:   C Montagut et al. Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res. 2008, 68(12), 4853–4861. [online]   G Hatzivassiliou et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 2010, 464, 431-435. [online]     Chemical Name: 3-(Cyano-dimethyl-methyl)-N-[4-methyl-3-(3-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylamino)-phenyl]-benzamide   AZ 628 | C-Raf inhibitor | Axon Medchem | Axon 1545 | AZ628

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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Axon Ligands In The Field:

AZ 628 | C-Raf inhibitor

GDC 0879 | B-Raf inhibitor

PLX 4032 | B-Raf inhibitor

PLX 4720 | B-Raf inhibitor