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BIBW 2992  -  Afatinib

CAS 439081-18-2

C24H25ClFN5O3  MW 485.95 

Purity: 99%

Ordering Information:

Cat. No. Axon 1544    Prime Source

Qty1: 2 mg (research sample) / €90  $117

Qty2: 5 mg (research sample) / €125  $163

Promotion: 2 x 5 mg @ €200  $260

Qty3: 25 mg (research sample) / €435  $566

Promotion: 2 x 25 mg @ €700  $910

Qty4: on request contract research synthesis

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Biological Activity:   Second generation tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal receptor 2 (Her2 or ErbB 2) and EGFR (HER1) kinases. An investigational drug for breast cancer as well as other EGFR and Her2 driven cancers such as NSCLC and Head-and-Neck.   References: online 1 2   N Minkovsky and A Berezov. BIBW-2992, a dual receptor tyrosine kinase inhibitor for the treatment of solid tumors. Curr. Opin. Investig. Drugs 2008, 9(12), 1336–46. [online]   D Li et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene 2008, 27, 4702–4711. [online]   C Campas et al. BIBW-2992. Dual EGFR/HER2 inhibitor, oncolytic. Drugs Fut. 2008, 33(8), 649. [online]     Chemical Name: N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3''S'')-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4(dimethylamino)-2-butenamide

BIBW 2992 | EGFR/HER2 inhibitor | Axon Medchem | Axon 1544 | Afatinib - Tomtovok - Tovok - BIBW2992

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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