ZM 447439

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1541

CAS [331771-20-1]

MF C29H31N5O4
MW 513.59

Purity: 99%
Soluble in DMSO

ZM 447439

Description

Selective and ATP-competitive inhibitor of Aurora B kinase in vitro, with IC50 values to be 50, 250 and 1000 nM for Aurora B, C and A kinases respectively

BB Gadea and JV Ruderman. Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly, the completion of chromosome condensation, and the establishment of the spindle integrity checkpoint. Mol. Biol. Cell 2005, 16(3), 1305-1318.

AA Dar et al. Aurora Kinase Inhibitors - Rising Stars in Cancer Therapeutics? Mol. Cancer Ther. 2010, 9(2), 268 - 278.

F Girdler et al. Validating Aurora B as an anti-cancer drug target. J. Cell. Sci. 2006, 119, 3664-75.

C Ditchfield et al. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J. Cell. Biol. 2003, 161(2), 267-80.

I Georgieva et al. ZM447439, A novel promising aurora kinase inhibitor, Provokes antiproliferative and proapoptotic effects alone and in combination with Bio- and chemotherapeutic agents... Neuroendocrinol. 2010, 91(2), 121-130.

Aurora B inhibitor

Chemical name

N-{4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-ylamino]-phenyl}-benzamide

Parent CAS No.

[331771-20-1]

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Size	Unit Price	Stock
5 mg	€85.00	In Stock
25 mg	€240.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€120.00	In Stock
2 x 25 mg	€360.00	In Stock

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ZM 447439

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ZM 447439

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