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AT 7519 mesylate

CAS 902135-89-1 

C16H17Cl2N5O2.CH4O3S

MW 478.36  Purity: 99%

Ordering Information:

Cat. No. Axon 1539    Prime Source

Qty1: 5 mg (research sample) / €125  $163

Promotion: 2 x 5 mg @ €180  $234

Qty2: 25 mg (research sample) / €350  $455

Promotion: 2 x 25 mg @ €540  $702

Qty3: on request

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Biological Activity:   A small molecule inhibitor of multi-CDK, which inhibits CDK 1, 2 , 4, 5, 6, and 9 in vitro and induces apoptosis in multiple myeloma via GSK-3β activation and RNA polymerase II inhibition.   References:   L Sato et al. AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3β activation and RNA polymerase II inhibition. Oncogene 2010, 29, 2325-2336. [online]   MS Squires et al. AT7519, a cyclin-dependent kinase inhibitor, exerts its effects by transcriptional inhibition in leukemia cell lines and patient samples. Mol. Cancer Ther. 2010, 9(4), 920-928. [online]     Chemical Name: 4-(2,6-Dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide methanesulfonic acid

AT 7519 | CDK inhibitor | Axon Medchem | Axon 1539 | AT7519

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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