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JNJ 26854165  - Serdemetan

CAS 881202-45-5

C21H20N4  MW 328.42 

Purity: 99%

Soluble in DMSO to 46 mM

Ordering Information:

Cat. No. Axon 1538     Prime Source

Qty1: 5 mg (research sample) / €125  $163

Qty2: 25 mg (research sample) / €345  $449

Qty3: on request

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Biological Activity:   Oral HDM2 inhibitor (or antagonist), which showed potent activity against multiple myeloma (MM) cells in vitro and ex vivo; potential agent to restore p53 function and to potentially impact other HDM2 dependent pathways.   Note: Its directly water soluble form, JNJ26854165 dihydrochloride (Axon 1586), is also available.    References: online    T. Stühmer et al. A first-in-class HDM2-inhibitor (JNJ-26854165) in phase I development shows potent activity against multiple myeloma (MM) cells in vitro and ex vivo. J Clin Oncol 26: 2008 (May 20 suppl; abstr 14694)   K Kojima et al. The Novel Tryptamine Derivative JNJ-26854165 Induces Wild-Type p53- and E2F1-Mediated Apoptosis in Acute Myeloid and Lymphoid Leukemias. Mol. Cancer Ther. 2010, 9(9), 2545–2557. [online]       Chemical Name: N-[2-(1H-Indol-3-yl)-ethyl]-N'-pyridin-4-yl-benzene-1,3-diamine

JNJ 26854165  | HDM2 inhibitor | Axon Medchem | Axon 1538 | JNJ26864165

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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Axon Ligands In The Field:

HLI 373 | HDM2 inhibitor

JNJ 26854165 | HDM2 inhibitor

Nutlin 3 | MDM2 antagonist

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