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Biological Activity:
A oral, selective and potent ErbB-2 (HER2) kinase inhibitor; reported to inhibite HER2-driven cell line.
References:
JP Jani et al. Discovery and Pharmacologic Characterization of CP-724,714, a Selective ErbB2 Tyrosine Kinase Inhibitor. Cancer Res. 2007, 67(20), 9887-9893. [online]
PN Munster et al. First Study of the Safety, Tolerability, and Pharmacokinetics of CP-724,714 in Patients with Advanced Malignant Solid HER2-Expressing Tumors. Clin. Cancer Res. 2007, 13, 1238-1245. [online]
F Guo et al. Pharmacokinetics of a HER2 tyrosine kinase inhibitor CP-724,714 in patients with advanced malignant HER2 positive solid tumors: correlations with clinical characteristics and safety. Cancer Chemother. Pharmacol. 2008, 62(1), 97-109. [online]
Chemical Name: 2-methoxy-N-[(2E)-3-[4-[3-methyl-4-[6-methyl-3-pyridinyl)oxy]phenylamino]-(6-quinazolinyl]-2-propenyl]-acetamide
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