Thiazovivin | hESC survival enhancer | Axon Medchem | Axon 1535

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Thiazovivin

Tzv

CAS 1226056-71-8

C15H13N5OS MW 311.36

Purity: 99%

Soluble in DMSO to 100 mM

Ordering Information:

Cat. No. Axon 1535 Prime Source

Qty1: 5 mg (research sample) / 145 $189

Promotion: 2 x 5 mg @ 220 $286

Qty2: 25 mg (research sample) / 545 $709

Promotion: 2 x 25 mg @ 760 $988

Qty3: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Biological Activity:

A small molecule that enhances the survival of human embryonic stem cells (hESCs) after trypsinzation; ROCK inhibitor; Thiazovivin dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, when used in combination with ALK5 inhibitor SB 431542 (Axon 1661) and MEK inhibitor PD 0325091 (Axon 1408).

References:

T Lin and S Ding et al. A chemical platform for improved induction of human iPSCs. Nat. Methods. 2009, 6(11), 805-8. [online]

Y Xu and S Ding et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc. Natl. Acad. Sci. USA 2010, 107, 8129. [online]

Chemical Name: N-Benzyl-[2-(pyrimidin-4-yl)amino]thiazole-4-carboxamide

Thiazovivin | hESC survival enhancer | Axon Medchem | Axon 1535 | Tzv