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Dapivirine

R 147681 - TMC 120

 

 

CAS 244767-67-7

 C20H19N5  MW 329.41 

Purity: 99 %

 

 

 

 

Ordering Information:

 

Cat. No. Axon 1534

 

Qty1: 5 mg (research sample) / 125  $163

 

Qty2: 25 mg (research sample) / 375  $488

 

Qty3: on request

 

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

 

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Biological Activity:

 

Potent non-nucleoside reverse transcriptase inhibitor (NNRTI); an antiretroviral compound designed to prevent or interrupt HIV replication in human cells; safe and tolerable as potential vaginal microbicide.

 

References:

 

A David Woolfson et al. Intravaginal ring delivery of the reverse transcriptase inhibitor TMC 120 as an HIV microbicide. Int. J. Pharmaceutics. 2006, 325(1-2), 82-89. [online]

 

 

 

Chemical Name: 4-[4-(2,4,6-Trimethyl-phenylamino)-pyrimidin-2-ylamino]-benzonitrile

 

Dapivirine | NNRT inhibitor | Axon Medchem | Axon 1534

 

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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Axon Ligands in the field:

 

AG 7088 | HRV 3C inhibitor

Atazanivir | Protease inhibitor

D-Atazanivir | Protease inhibitor

Danoprevir | HCV protease inh.

Nelfinavir | Protease inhibitor

Dapivirine | NNRT inhibitor