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Osanetant - SR 142801

CAS 160492-56-8

C35H41Cl2N3O2  MW 606.64 

Purity: >98% (optically pure) 

Ordering Information:

Cat. No. Axon 1533   Prime Source Promotion

Qty1: 5 mg (research sample) / €135  $176

Qty2: 25 mg (research sample) / €485  $631

Qty3: on request

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Biological Activity:   Potent non-peptide neurokinin 3 (NK3) receptor antagonist.    References: online   X Emonds-Alt et al. SR 142801, the first potent non-peptide antagonist of the tachykinin NK3 receptor. Life Sci. 1995, 56(1), PL27-32.   F Kamali. Osanetant Sanofi-Synthélabo. Curr. Opin. Invest. Drugs. 2001, 2(7), 950-956.   L Quartara and M Altamura. Tachykinin receptors antagonists: from research to clinic. Curr. Drug Targets. 2006, 7(8), 975-992.   MA De Souza Silva et al. The tachykinin NK3 receptor antagonist SR142801 blocks the behavioral effects of cocaine in marmoset monkeys. Eur. J. Pharmacol. 2006, 536(3), 269-278.   G Jocham et al. Neurokinin receptor antagonism attenuates cocaine's behavioural activating effects yet potentiates its dopamine-enhancing action in the nucleus accumbens core. Eur. J. Neurosci. 2006, 24(6), 1721-1732.     Chemical Name: N-(1-{3-[(3R)-1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]propyl}-4-phenylpiperidin-4-yl]-N-methylacetamide

Osanetant - SR 142801 | NK3 antagonist | Axon Medchem | Axon 1533 | SR142801

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Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.