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RD 162 - RD162

CAS 915087-27-3 

C22H16F4N4O2S MW 476.46

Purity: >98%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1532     Exclusive Promotion

Qty1: 5 mg (research sample) / €135  $176

Qty2: 25 mg (research sample) / €540  $702

Qty3: on request contract research synthesis

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Biological Activity:   An orally active and very potent antagonist of androgen receptor (AR); Second-generation of antiandrogen for the treatment of advanced prostate cancer; highly recommended tool in AR research.   References: online   C Tran et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 2009, 324 (5928), 787-790. [online]   C Harrison. Anticancer drugs: New approaches to anti-androgen activities. Nature Reviews Drug Discovery 2009, 8, 452-453. [online]   CJ Hoimes and WK Kelley. Redefining hormone resistance in prostate cancer. Ther Adv Med Oncol. 2010, 2(2), 107–123. [online]     Chemical Name: 4-[7-(4-Cyano-3-trifluoromethyl-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-N-methyl-benzamide

RD 162 | Antiandrogen | Axon Medchem | Axon 1532 | RD162

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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