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RO 3306

CAS 872573-93-8

C18H13N3OS2  MW 351.4

Purity: 98%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1530     Prime Source

Qty1: 5 mg (research sample) / €125  $163

Promotion: 2 x 5 mg @ €180  $234

Qty2: 25 mg (research sample) / €475  $618

Promotion: 2 x 25 mg @ €680  $884

Qty3: on request

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Biological Activity:   Selective CDK 1 inhibitor (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively), which induces cell cycle arrest and actively enhances downstream p53 signaling to promote apoptosis in AML cell lines.   References:   LT Vassilev et al. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc Natl Acad Sci USA. 2006, 103(28), 10660–10665. [online]   K Kojima et al. The CDK1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML. Cancer Sci. 2009, 100(6), 1128–1136. [online]     Chemical Name: (5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one

RO 3306 | CDK 1 inhibitor | Axon Medchem | Axon 1530 | RO3306

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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Axon Ligands In The Field: 

AT 7519 | CDK inhibitor

RO 3306 | CDK 1 inhibitor

SCH 727965 | CDK inhibitor

SNS 032 | CDK 2 inhibitor

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