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BI-D1870

CAS 501437-28-1

C19H23F2N5O2  MW 391.42

Purity: 99%

Soluble in DMSO >100 mM

Ordering Information:

Cat. No. Axon 1528    2012 Promotion

Qty1: 2 mg (research sample) / €100  $130

Qty2: 5 mg (research sample) / €145  $189

Promotion: 2 x 5 mg @ €220  $286

Qty3: 25 mg (research sample) / €545  $709

Promotion: 2 x 25 mg @ €800  $1040

Qty4: on request

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Biological Activity:   Potent and specific inhibitor of the p90 ribosomal S6 kinase (RSK) isoforms in vitro and in vivo, which inhibits RSK1, RSK2, RSK3 and RSK4 in vitro with an IC50 of 10–30 nM.   References:   GP Sapkota et al. BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. Biochem. J. 2007, 401, 29–38. [online]   TL Nguyen. Targeting RSK: An Overview of Small Molecule Inhibitors. Anti-Cancer Agents Med. Chem. 2008, 8, 710-716. [online]   R Zaru et al. The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Nature Immunology 2007, 8, 1227 - 1235. [abstract] [Figure 2]     Chemical Name: 2-(3,5-Difluoro-4-hydroxy-phenylamino)-5,7-dimethyl-8-(3-methyl-butyl)-7,8-dihydro-5H-pteridin-6-one

BI-D1870 | p90 RSK inhibitor | Axon Medchem | Axon 1528 | BI-D 1870

Axon Ligands^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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