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XAV 939 - NVP-XAV939

CAS 284028-89-3

C14H11F3N2OS  MW 312.32

Purity: >99 %

Ordering Information:

Cat. No. Axon 1527   Prime Source

Qty1: 10 mg / €95  $124

Qty2: 25 mg / €185  $241

Promotion: 2 x 25 mg @ €280  $364

Qty3: on request (*in stock of multigrams)

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Biological Activity:   Tankyrase (TNKS) inhibitor, with IC50 values to be 11 and 4 nM for TNKS1 and TNKS2 respectively; inhibiting Wnt / β-catenin signaling.   References:   SM Huang et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signaling. Nature 2009, 461, 614-620. [online] R Nusse. Wnt signaling and stem cell control. Cell Res. 2008, 18, 523-527. [online]   RT Peterson, Propping up a destructive regime. Nature 2009, 461, 599–600. [online]   EM Adler. Inhibiting Wnt signaling. Sci. Signal. 2009, 2(91), ec326. [online]   CE Meacham et al. In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression. Nature Gen. 2009, 41(10), 1131-1137. [online]     Chemical Name: 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol

XAV 939 | TNKS inhibitor | Axon Medchem | Axon 1527 | NVP-XAV939

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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