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Neratinib - HKI 272

CAS 698387-09-6

C30H29ClN6O3  MW 557.09 

Purity: >98%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1526    Prime Source

Qty1: 5 mg (research sample) / €125  $163

Promotion: 2 x 5 mg @ €180  $234

Qty2: 25 mg (research sample) / €425  $553

Promotion: 2 x 25 mg @ €640  $832

Qty3: on request

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Biological Activity:   An irreversible tyrosine kinase inhibitor with activity against HER2 and EGFR kinases; a therapeutic agent under investigation for the treatment breast cancer and other solid tumours.   References: online 12   SK Rabindran et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res. 2004, 64(11), 3958–65. [online]   Y Minami et al. The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor HKI-272. Oncogene 2007, 26(34), 5023–7. [online]   A Ocaña and E Amir. Irreversible pan-ErbB tyrosine kinase inhibitors and breast cancer: current status and future directions. Cancer Treat Rev. 2009, 5(8), 685-691. [online]     Chemical Name: (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide

Neratinib | EGFR/HER2 inhibitor | Axon Medchem | Axon 1526 | HKI 272 - HKI272

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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