Retigabine - D 23129 | KCNQ/Kv7 channel opener | Axon Medchem

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Retigabine

D 23129 - Ezogabine

CAS 150812-12-7

C16H18FN3O2 MW 303.33

Purity: 99%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1525

Qty1: 10 mg (research sample) / €99 $129

Qty2: 50 mg (research sample) / €265 $345

Qty3: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Biological Activity:

Selective neuronal KCNQ/Kv7 potassium channel opener; an anticonvulsant in development for the potential oral treatment of complex partial seizures and post-herpetic neuralgia (PHN).

References: online

Retigabine. WHO Drug Information 1997; 11/3: 177.

R Hempel et al. Metabolism of retigabine (D-23129), a novel anticonvulsant. Drug Metab. Disposit. 1999, 27(5), 613-622.

MPG Korsgaard et al. Anxiolytic Effects of Maxipost (BMS-204352) and Retigabine via Activation of Neuronal Kv7 Channels. J. Pharmacol. Exp. Ther. 2005, 314, 282-292.

Chemical Name: ethyl 2-amino-4-[(p-fluorobenzyl)amino]carbanilate

Retigabine - D 23129 | KCNQ/Kv7 channel opener | Axon Medchem | Axon 1525 - D23129 - Ezogabine