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Biological Activity:
an analgesic agent, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors, with a Ki of 11 nM at CB1 and 33 nM at CB2.
References: online
JW Huffman et al. 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg. Med. Chem. Lett. 2005, 15(18), 4110-4113.
C Manera et al. Indoles and related compounds as cannabinoid ligands. Mini Rev. Med. Chem. 2008, 8(4), 370-387.
R Lindigkeit et al. Spice: A never ending story? Forensic Sci. Int. 2009, 191(1-3), 58-63. [online]
Baker et al. Cannabinoids control spasticity and tremor in a multiple sclerosis model. Nature 2000, 404, 84.
Chemical Name: 2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone
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