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Sitamaquine tosylate - WR 6026

CAS 1019640-33-5

57695-04-2 (free base) 

C21H33N3O.C7H8O3S MW 515.72

Purity: 99%

Ordering Information:

Cat. No. Axon 1515      

Qty1: 10 mg (research sample) / €125  $163

Qty3: 50 mg (research sample) / €425  $553

Qty4: on request or contract research synthesis

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Biological Activity:   A potential agent as an oral treatment of life-threatening visceral leishmaniasis (VL) caused by Leishmania donovani, with an IC50 of 29.2 μM against the promastigote form in vitro.   References:   AM Duenas-Romero et al. Interaction of sitamaquine with membrane lipids of Leishmania donovani promastigotes. Biochim. Biophy. Acta (BBA) - Biomembranes 2007, 1768(2), 246-252. [online] C Lopez-Martin et al. Sitamaquine Sensitivity in Leishmania Species Is Not Mediated by Drug Accumulation in Acidocalcisomes. Antimicrob. Agents Chemother. 2008, 52(11), 4030-4036. [online]   Chemical Name: N,N-diethyl-N'-(6-methoxy-4-methyl-quinolin-8-yl)hexane-1,6-diamine tosylate

Sitamaquine - WR 6026 | antileishmania | Axon Medchem | Axon 1515 | WR6026

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Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.