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TMI 005 - Apratastat

CAS 287405-51-0

C17H22N2O6S2  MW 414.50

Purity: 99%

Ordering Information:

Cat. No. Axon 1507   Prime Source Promotion

Qty1: 5 mg (research sample) / €135  $176

Qty2: 25 mg (research sample) / €475  $618

Qty3: on request

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Biological Activity:   Novel, oral TACE/MMP inhibitor for rheumatoid arthritis; Apratastat (TMI-005) blocks secretion of soluble TNF-α and down regulates multiple MMPs, which have been implicated in cartilage destruction and bone erosions of RA.   References:   MM Thabet and TWJ Huizinga. Apratastat, a novel TACE/MMP inhibitor for rheumatoid arthritis. Curr. Opin. Investig. Drugs. 2006, 7(11), 1014-1019.   ML Moss et al. Drug Insight: Tumor Necrosis Factor Converting Enzyme as a Pharmaceutical Target for Rheumatoid Arthritis. Nat. Clin. Pract. Rheumatol. 2008, 4(6), 300. [online]   Chemical Name: 4-((4-(2-butynyloxy)phenyl)sulfonyl)-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide

TMI 005 - Apratastat | TACE/MMP inhibitor | Axon Medchem | Axon 1507 | TMI005

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Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.