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GDC-0449

Vismodegib - HhAntag691

CAS 879085-55-9

C19H14Cl2N2O3S  MW 421.31 

Purity: 99%

Ordering Information:

Cat. No. Axon 1500    Prime Source Promotion

Qty1: 5 mg (research sample) / €105  $137

Promotion: 2 x 5 mg @ €150  $195

Qty2: 25 mg (research sample) / €305  $397

Promotion: 2 x 25 mg @ €450  $585

Qty3: on request contract research synthesis

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Biological Activity:   The first-in-class inhibitor of Hedgehog (Hh) signaling pathway; more specifically, an orally bioavailable and potent inhibitor of smoothened homologue (SMO); an investigational anti-cancer drug for Medulloblastoma, advanced basal cell skin cancer etc.   References:   CM Rudin et al. Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449. N. Engl. J. Med. 2009, 361, 1173-8. [online]   SJ Scales and FJ de Sauvage. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol. Sci. 2009, 30(6), 303-312. [online]     Chemical Name: 2-Chloro-N-(4-chloro-3-pyridin-2-yl-phenyl)-4-methanesulfonyl-benzamide

GDC-0449 | Hedgehog pathway inhibitor | Axon Medchem | Axon 1500 | GDC0449 - Vismodegib - HhAntag691

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.