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CP 466722

CAS 1080622-86-1

C17H15N5O2 MW 349.35

Purity: 99%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1495    2012 Promotion

Qty1: 2 mg (research sample) / €95  $124

Qty2: 5 mg (research sample) / €145  $189

Promotion: 2 x 5 mg @ €220  $286

Qty3: 25 mg (research sample) / €545  $709

Promotion: 2 x 25 mg / €780  $1014

Qty4: on request

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Biological Activity:   Specific ATM inhibitor; no inhibition of PI3K or PI3K-like protein kinases (PIKK) or Abl kinase in cells; does inhibit cellular ATM-dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects; highly recommended tool to rapidly and revesibly regulate ATM activity.   References:   MD Rainey et al. Transient inhibition of ATM kinase is sufficient to inhance cellular sensitivity to ionizing radiation. Cancer Res. 2008, 68(18), 7466-7474.   F Dumont et al. Radiosensitising agents for the radiotherapy of cancer: novel molecularly targeted approaches. Expert Opin. Ther. Pat. 2009, 19(6), 775-799. [online]     Chemical Name: 2-(6,7-dimethoxyquinazolin-4-yl)-5-(pyridiin-2-yl)-2H-1,2,4-triazol-3-amine

CP 466722 | ATM inhibitor | Axon Medchem | Axon 1495 | CP466722

Axon Ligands ^TM  - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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