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Aprepitant

CAS 170729-80-3
C23H21F7N4O3  MW 534.43

Purity: 99% (optically pure)

Ordering Information:

Cat. No. Axon 1486   Prime Source

Qty1: 5 mg (research sample) / €185  $241

Promotion: 10 mg @ €240  $312

Qty2: 25 mg (research sample) / €585  $761

Promotion: 50 mg @ €820  $1066

Qty3: on request

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Biological Activity:   Substance P antagonist (SPA), having effect by blocking the neurokinin 1 (NK1) receptor.   References: online   K Ranga and R Krishnan. Clinical experience with substance P receptor (NK1) antagonists in depression. J. Clin. Psychiatry 2002, 63 Suppl 11, 25-9.   AK Majumdar et al. Effects of aprepitant on cytochrome P450 3A4 activity using midazolam as a probe. Clin. Pharmacol. Ther. 2003, 74, 150–156. [abstract]       Chemical Name: 5-([(2R,3S)-2-((R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluorophenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one

Aprepitant | NK1 antagonist | Axon Medchem | Axon 1486 | Emend - MK 869 - MK869

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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Axon Ligands In The Field:

Aprepitant | NK1 antagonist

TAK 637 | NK1 antagonist

GR 159897 | NK2 antagonist

Osanetant | NK3 antagonist