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Biological Activity:
Inhibitor of γ-secretase; blocks notch signaling and enhances neuron cell differentiation.
References:
J Kanungo et al. The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins J. Neurochem. 2008, 106, 2236-2248.
TQ Crawford, H Roelink. The notch response inhibitor DAPT enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independently of sonic hedgehog signaling. Dev Dyn. 2007, 236(3), 886-92. [online]
TV Arumugam et al. Gamma secretase–mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nature Medicine 2006, 12, 621-623. [online]
CA Micchelli et al. γ-Secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. FASEB J. 2003, 17, 79-81.
Chemical Name: N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycin e-1,1-dimethylethyl ester; aka γ-Secretase inhibitor IX
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