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MK 0524 sodium salt - Laropiprant

CAS 571170-77-9 (parent)

572874-50-1 (sodium salt)

C21H18ClFNO4S.Na

Purity: 99% (optically pure)

Ordering Information:

Cat. No. Axon 1480    Prime Source Promotion

Qty1: 5 mg (research sample) / €125  $163

Qty2: 25 mg (research sample) / €425  $553

Qty3: on request contract research synthesis

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Biological Activity:   Potent and selective prostaglandin D2 (PGD2) receptor 1 (DP1) antagonist; Ki values to be 0.57 nM and 750 nM for DP1 and DP2 receptors respectively.   References:   K Chang et al. Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. PNAS 2006, 103(17), 6682-6687. [online]   CF Sturino et al. Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524). J. Med. Chem. 2007, 50(4), 794-806. [abstract]     Chemical Name: [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid sodium salt

MK 0524 | DP1 antagonist | Axon Medchem | Axon 1480 | MK0524 - Laropiprant

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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