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Biological Activity:
Selective 5-HT4 receptor agonist; a gastroprokinetic agent for the treatment of constipation and irritable bowel syndrome; showed memory-enhancing effects in mice through modulation of cholinergic pathways; hence an indication of potential as Alzheimer's disease therapy.
References: online
EP Bouras et al. Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans. Gut. 1999, 44(5), 682-6.
JH De Maeyer et al. 5-HT4 receptor agonists: similar but not the same. Neurogastroenterol. Motility. 2008, 20(2), 99-112.
J Tack et al. Prucalopride (resolor(R)) in the treatment of severe chronic constipation in patients dissatisfied with laxatives. Gut. 2009, 58(3), 357-65. [abstract]
M Cachard-Chastel et al. Prucalopride and donepezil act synergistically to reverse scopolamine-induced memory deficit in C57Bl/6j mice. Behav. Brain Res. 2008, 187(2), 455-61.
Chemical Name: 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide
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