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Biological Activity:
Potent and selective mTOR inhibitor, with IC50 values to be about 10 nM for mTORC1 and mTORC2.
References:
J Garcia-Martinez et al. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem. J. 2009, 421, 29-42. [online]
K Garber. Targeting mTOR: Something Old, Something New. J. Nat. Can. Inst 2009, 101(5),288-290. [online]
K Malagu et al. The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase. Bioorg. Med. Chem. Lett. 2009, 19(20), 5950-5953. [online]
Chemical Name: {5-[2-((2S,6R)-2,6-Dimethyl-morpholin-4-yl)-4-morpholin-4-yl-pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-phenyl}-methanol
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