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Biological Activity:
Selective 5-ht5A receptor antagonist.
References:
DF Corbett et al. Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry. Bioorg. Med. Chem. Letts. 2005, 15, 4014. [abstract]
DR Thomas et al. SB-69951-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: evidence for an autoreceptor role for the 5-ht5A receptor in guinea pig brain. Neuropharmacology 2006, 51, 566. [abstract]
DR Thomas. 5-ht5A receptors as a therapeutic target. Pharmacol. Ther. 2006, 111, 707. [abstract]
Chemical Name: N-[2-(Dimethylamino)ethyl]-N-[[4'-[[(2-phenylethyl)amin o]methyl][1,1'-biphenyl]-4-yl]methyl]cyclopentanepropan amide dihydrochloride
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