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A 769662

CAS 844499-71-4

C20H12N2O3S  MW 360.39

Purity: 99%

Ordering Information:

Cat. No. Axon 1466    

Qty1: 5 mg / €95  $124

Promotion: 2 x 5 mg @  €140   $182

Qty2: 25 mg / €235  $306

Promotion: 2 x 25 mg @  €360   $468

Qty3: on request

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or by fax to: +31-50-3600390.

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Biological Activity:   Potent and selective activator of AMP-activated protein kinase (AMPK) β1 subunit-containing complexs.   References:   B Cool et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metabolism. 2006, 3, 403. [abstract]   M Sanders et al. Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. J. Biol. Chem. 2007, 282, 32539. [abstract]   O Göransson et al. Mechanism of Action of A-769662, a Valuable Tool for Activation of AMP-activated Protein Kinase. J. Biol. Chem. 2007, 282, 32549-32560. [abstract]   JW Scott et al. Thienopyridone drugs are selective activators of AMP-activated protein kinase β1-containing complexes. Chem. Biol. 2008, 15, 1220. [abstract]   JT Treebak et al. A-769662 activates AMPK β1-containing complexes but induces glucose uptake through a PI3 kinase-dependent pathway in mouse skeletal muscle. Am. J. Physiol. Cell Physiol. 2009, 0, 00051. [abstract]     Chemical Name: 4-Hydroxy-3-(2'-hydroxy-biphenyl-4-yl)-6-oxo-6,7-dihydro-thieno[2,3-b]pyridine-5-carbonitrile

A 769662 | AMPK activator | Axon Medchem | Axon 1466 | A769662