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Biological Activity:
Potent, cell-permeable and selective inhibitor of p38 MAP kinase (MAPK); water-soluble salt of SB 203580 (Axon 1363).
References: online 1, 2
PC Singhal et al. Role of P38 Mitogen-Activated Protein Kinase Phosphorylation and Fas-Fas Ligand Interaction in Morphine-Induced Macrophage Apoptosis. J. Immunol. 2002, 168, 4025-4033.
PR Young et al. Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site. J. Biol. Chem. 1997, 272, 12116-12121.
H Kankaanranta et al. SB 203580, an Inhibitor of p38 Mitogen-Activated Protein Kinase, Enhances Constitutive Apoptosis of Cytokine-Deprived Human Eosinophils. J. Pharm. Exp. Ther. 1999, 290, 2, 621-628.
Chemical Name: 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole hydrochloride
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