NU 7441 | DNA-PK inhibitor | Axon Ligands

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NU 7441 - KU 57788

CAS 503468-95-9

C25H19NO3S MW 413.50

Purity: 99%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1463 Prime Source

Qty1: 2 mg (research sample) / 80 $104

Qty2: 5 mg (research sample) / 135 $176

Promotion: 2 x 5 mg / 180 $234

Qty3: 25 mg (research sample) / 450 $585

Promotion: 2 x 25 mg / 620 $806

Qty4: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Biological Activity:

Potent, selective and ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK), with IC50 value to be 13 nM for in vitro DNA-PK inhibition; selectivity >100 fold for DNA-PK over related kinases.

References:

E Willmore et al. DNA-Dependent Protein Kinase Is a Therapeutic Target and an Indicator of Poor Prognosis in B-Cell Chronic Lymphocytic Leukemia. Clin. Cancer Res. 2008, 14(12), 3984. [abstract]

Y Zhao et al. Preclinical Evaluation of a Potent Novel DNA-Dependent Protein Kinase Inhibitor NU7441. Cancer Research 2006, 66, 5354-5362. [abstract]

M Ljungman. Targeting the DNA damage response in cancer. Chem. Rev. 2009, 109(7), 2929-50.

Chemical Name: 8-Dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one

NU 7441 | DNA-PK inhibitor | Axon Medchem | Axon 1463 | KU 57788 - KU57788 - NU7441