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NU 7441 - KU 57788

CAS 503468-95-9 

C25H19NO3S  MW 413.50 

Purity: 99%

Soluble in DMSO

 

 

 

 

 

Ordering Information:

 

Cat. No. Axon 1463     Prime Source

 

Qty1: 2 mg65  $85

Qty2: 5 mg / 95  $124

Promotion: 2 x 5 mg @ 140  $182

Qty3: 25 mg / 295  $384

Promotion: 2 x 25 mg @ 440  $572

Qty4: on request

 

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or by fax to: +31-50-3600390.

 

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Biological Activity:

 

Potent, selective and ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK), with IC50 value to be 13 nM for in vitro DNA-PK inhibition; selectivity >100 fold for DNA-PK over related kinases.

 

References:

 

E Willmore et al. DNA-Dependent Protein Kinase Is a Therapeutic Target and an Indicator of Poor Prognosis in B-Cell Chronic Lymphocytic Leukemia. Clin. Cancer Res. 2008, 14(12), 3984. [abstract]

 

Y Zhao et al. Preclinical Evaluation of a Potent Novel DNA-Dependent Protein Kinase Inhibitor NU7441.  Cancer Res. 2006, 66, 5354-5362. [abstract]

 

M Ljungman. Targeting the DNA damage response in cancer. Chem. Rev. 2009, 109(7), 2929-50.

 

 

Chemical Name: 8-Dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one 

 

NU 7441 | DNA-PK inhibitor | Axon Medchem | Axon 1463 | KU 57788 - KU57788 - NU7441 supplier

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

axonmedchem.com 2013

 

Axon PI3K and PIKK Inhibitors:

(Click to enter)

 

KU 0060648 | DNA-PK inhibitor

NU 7441 | DNA-PK inhibitor

 

A 66 | PI3K p110α inhibitor

AS 252424 | PI3K p110γ inhibitor

BEZ 235 | PI3K/mTOR inhibitor

BKM 120 | PI3K inhibitor

D-106669 | PI3K inhibitor

GDC 0941 | PI3K inhibitor

GDC 0980 | PI3K/mTOR inhibitor

GSK 2126458 | PI3K/mTOR inh.

LY 294002 | PI3K Inhibitor

PF 04691052 | PI3K/mTOR inh.

PIK 75 | PI3K p110α inhibitor

PIK 90 | PI3K p110α inhibitor

PKI 587 | PI3K/mTOR inhibitor

TGX 221 | PI3K p110β inhibitor

XL 765 | PI3K/mTOR inhibitor

AZD 8055 | mTOR inhibitor

KU 0063794 | mTOR inhibitor

Palomid 529 | Akt/mTOR inhibitor

Temsirolimus | mTOR inhibitor

Torin 1 | mTOR inhibitor

Torin 2 | mTOR inhibitor

CP 466722 | ATM inhibitor

KU 55933 | ATM inhibitor

VE 821 | ATR inhibitor

 

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