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NS 11394- NS11394

CAS 951650-22-9

C23H19N3O  MW 353.43

Purity: 99 %

Ordering Information:

Cat. No. Axon 1457    Exclusive Promotion

Qty1: 5 mg (research sample) / €115  $150

Promotion: 2 x 5 mg @ €180  $234

Qty2: 25 mg (research sample) / €345  $449

Promotion: 2 x 25 mg @ €560  $728

Qty3: on request

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Biological Activity:   A unique subtype-selective GABAA receptor positive allosteric modulator (PAM); with a subtype selectivity profile at GABAA receptors of α5 > α3 > α2 > α1. Compared with other subtype-selective ligands, NS11394 is unique in having superior efficacy at GABAA-α3 receptors while maintaining low efficacy at GABAA-α1 receptors, which might be attributed for its significantly reduced side effect profile in rat.    References: online   NR Mirza, et al, NS11394 [3'-[5-(1-Hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a Unique Subtype-Selective GABAA Receptor Positive Allosteric Modulator: In Vitro Actions, Pharmacokinetic Properties and in Vivo Anxiolytic Efficacy. J. Pharmacol. Exp. Ther. 2008, 327, 954-968.   G. Munro et al. Comparison of the Novel Subtype-Selective GABAA Receptor-Positive Allosteric Modulator NS11394 [3'-[5-(1-Hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with Diazepam, Zolpidem, Bretazenil, and Gaboxadol in Rat Models of Inflammatory and Neuropathic Pain. J. Pharmacol. Exp. Ther. 2008, 327, 969-981.     Chemical Name: 3'-[5-(1-Hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile

NS 11394 | GABAA PAM | Axon Medchem | Axon 1457 | NS11394

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research and synthesis.

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