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Granisetron hydrochloride

BRL 43694

CAS 107007-99-8

109889-09-0 (free base)

C18H24N4O.HCl MW 348.87

Purity: 99 %

Ordering Information:

Cat. No. Axon 1449

Qty1: 25 mg / €85  $111

Qty2: 100 mg / €255  $332

Qty3: on request (*in stock of multigrams)

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or by fax to: +31-50-3600390.

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Biological Activity:   Serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy; water-soluble form.   References: online   Plosker and Goa. Granisetron. A review of its pharmacological properties and therapeutic use as an antiemetic. Drugs 1992, 42, 805.   Sanger and Nelson. Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron). Eur.J.Pharmacol. 1989, 159, 113.       Chemical Name: 1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3- yl]-1H-indazole-3-carboxamide hydrochloride

Granisetron | 5-HT3 antagonist | Axon Medchem | Axon 1449

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

Axon Ligands In The Field:

Alosetron | 5-HT3 antagonist

Azasetron | 5-HT3 antagonist

Granisetron | 5-HT3 antagonist

Other 5-HT Ligands: e.g.