Axon Ligands (TM) - alphabetic: [A] [B] [C] [D] [E] [F] [G] [H] [I] [J] [K] [L] [M] [N] [O] [P] [Q] [R] [S] [T] [U] [V] [W] [X] [Y] [Z]

Caprospinol - SP 233

CAS 4592-56-1

 C33H52O4 MW 512.78

Purity: 99% (optically pure)

Ordering Information:

Cat. No. Axon 1442    Prime Source Promotion

Qty1: 10 mg (research sample) / €145  $189

Qty2: 50 mg (research sample) / €545  $709

Qty3: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Contact us for our product range and services.

Biological Activity:   An efficacious therapeutic indicated in Alzheimer’s disease (AD); clearing beta-amyloid plaque in-vivo; restoring memory in rats.   Caprospinol binds to Ab1-42 and blocks its oligomerization into the highly neurotoxic species Amyloid Derived Diffusible Ligands (ADDLs); having neuroprotective effects as a result of a direct effect at the mitochondria level.   References: online 1 2   L Lecanu et al. Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease. Neurosci. 2010, 165(2), 427-35. [online]   L Lecanu et al. Caprospinol: moving from a neuroactive steroid to a neurotropic drug. Exp. Opin. Invest. Drugs, 2009, 18(3), 265-276(12). [online]     Chemical Name: (22R,25R)-20α-spirost-5-en-3β-yl hexanoate

Caprospinol - SP233 | AD therapeutic | Axon Medchem | Axon 1442

axonmedchem.com © 2010

Axon Ligands ^TM    

Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.