Axon Ligands (TM) - alphabetic: [A] [B] [C] [D] [E] [F] [G] [H] [I] [J] [K] [L] [M] [N] [O] [P] [Q] [R] [S] [T] [U] [V] [W] [X] [Y] [Z]

Donepezil hydrochloride

E2020

CAS 120011-70-3

120014-06-4 (free base)

 C24H29NO3.HCl  MW 415.96

Purity: 99%

Soluble in water and DMSO

Ordering Information:

Cat. No. Axon 1438    

Qty1: 10 mg / €95  $124

Promotion: 25 mg @ €125  $163

Qty2: 50 mg / €285  $371

Promotion: 100 mg @ €360  $468

Qty3: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Contact us for payment and tech support.

Biological Activity:   A centrally acting reversible acetylcholinesterase (AChE) inhibitor (IC50: 5.7 nM), with 100% oral bioavailability and easily crossing the blood-brain barrier; therapeutic agent in the treatment of Alzheimer's disease.   References: online 1   J Birks, RJ Harvey. Donepezil for dementia due to Alzheimer's disease. Cochrane Database Syst Rev 2006, (1): CD001190. [abstract]   LS Steele, RH Glazier. Is donepezil effective for treating Alzheimer's disease? Can Fam Physician 1999, 45, 917–9. [abstract]   G Xiong, PM Doraiswamy. Combination drug therapy for Alzheimer's disease: what is evidence-based, and what is not?. Geriatrics 2005, 60(6), 22–6. [abstract]       Chemical Name: 2-[(1-benzyl-4-piperidyl)methyl]- 5,6-dimethoxy-2,3-dihydroinden-1-one hydrochloride

Donepezil | AChE inhibitor | Axon Medchem | Axon 1438 | Aricept - E2020

axonmedchem.com © 2012

Axon Ligands In The Fields:

Donepezil | AChE inhibitor

Axon Ligands ^TM    

Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.