AS 252424 bispotassium salt - AS 252424K

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 1436

CAS [N.A.]

MF C14H6FNO4S.K2
MW 381.46

Purity: 99%
Soluble in water and DMSO

AS 252424 bispotassium salt

Description

Potent and selective PI3K p110γ inhibitor; IC50 values for inhibition of human recombinant PI3Kγ, α, β, and δ to be 30, 940, 20,000, and 20,000 nM respectively; water-soluble bispotassium salt form of AS 252424 (Axon 1424).

V. Pomel et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. J. Med. Chem. 2006, 49, 3857-3871.

T. Rückle et al. PI3Kgamma inhibition: towards an 'aspirin of the 21st century'? Nat. Rev. Drug Discov. 2006, 5, 903-918.

B.T. Hennessy et al. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat. Rev. Drug Discov. 2005, 4, 988-1004.

A.M. Condliffe et al. Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood. 2005, 106, 1432-1440.

PI3K inhibitor (p110-γ specific)

Chemical name

Bispotassium 5-[1-[5-(4-Fluoro-2-hydroxy-phenyl)-furan-2-yl]-meth-(Z)-ylidene]-thiazolidine-2,4-dione

Parent CAS No.

[900515-16-4]

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5 mg	€95.00	In Stock
25 mg	€305.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€140.00	In Stock
2 x 25 mg	€440.00	In Stock

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AS 252424 bispotassium salt - AS 252424K

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AS 252424 bispotassium salt - AS 252424K

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