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(S)-(+)-Rolipram

CAS 85416-73-5

C16H21NO3  MW 275.34

Purity: 99%, >98%ee

Soluble in DMSO to 100 mM

Ordering Information:

Cat. No. Axon 1432

Qty1: 10 mg / €115  $150

Qty2: 50 mg / €415  $540

Qty3: on request

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Biological Activity:   PDE4 inhibitor, less active S-enantiomer of Rolipram (Axon 1212) in comparison with the opposite (R)-(-)-Rolipram (Axon 1229).   References:   HH Schneider et al. Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur. J. Pharmacol. 1986, 127(1-2), 105-15. [online]   DE Griswold et al. Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response. Inflammation. 1993, 17(3), 333–44.   SJ Kanes et al. Rolipram: A specific phosphodiesterase 4 inhibitor with potential antipsychotic activity. Neuroscience. 2006, 144, 239-46. PMID 17081698   RW Chen et al. Broad spectrum neuroprotection profile of phosphodiesterase inhibitors as related to modulation of cell-cycle elements and caspase-3 activation. Neuroscience Letters. 2007, 418(2), 165–9.     Chemical Name: (S)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one

(S)-(+)-Rolipram | PDE4 inhibitor | Axon Medchem | Axon 1432

Axon Ligands In The Field: