CPPHA | mGluR5 PAM | Axon Ligands

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CPPHA

CAS 693288-97-0

C22H15ClN2O4 MW 406.82

Purity: 99%

Soluble in DMSO to 60 mM

Ordering Information:

Cat. No. Axon 1431 Prime Source

Qty1: 5 mg / 125 $163

Promotion: 2 x 5 mg @ 180 $234

Qty2: 25 mg / 425 $553

Promotion: 2 x 25 mg @ 600 $780

Qty3: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Biological Activity:

A positive allosteric modulator (PAM) of metabotropic glutamate receptor subtype 5 (mGluR5)

References:

J O'Brien et al. A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain. J. Pharmacol. Exp. Ther. 2004, 309, 568-577. [abstract]

Y Chen et al. N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) Acts through a Novel Site as a Positive Allosteric Modulator of Group 1 Metabotropic Glutamate Receptors. Mol. Pharmacol. 2008, 73, 909-918. [abstract]

Chemical Name: N-[4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide

CPPHA | mGluR5 PAM | Axon Medchem | Axon 1431

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.