VU-29 | PAM of mGluR5 | Axon Ligands | Axon Medchem

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VU-29

CAS 890764-36-0

C22H16N4O3 MW 384.40

Purity: 99%

Soluble in DMSO to 48 mM

Ordering Information:

Cat. No. Axon 1425 Prime Source

Qty1: 10 mg / 125 $163

Qty2: 50 mg / 375 $488

Qty3: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Biological Activity:

A Positive Allosteric Modulator (PAM) of metabotropic glutamate receptor subtype 5 (mGluR5)

References:

JE Ayala et al. A Positive Allosteric Modulator of mGluR5 Potentiates DHPG-induced Long Term Depression at the Schaffer CollateralCA1 Synapse of the Rat Hippocampus. FASEB J. 2008, 22, 714.4. [abstract]

Y Chen et al. Interaction of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 5 with the Negative Allosteric Antagonist Site Is Required for Potentiation of Receptor Responses. Mol. Pharmacol. 2007, 71, 13891398.

Chemical Name: 4-Nitro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide

VU 29 | mGluR5 PAM | Axon Medchem | Axon 1425 | VU29

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.