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Biological Activity:
Potent and selective PI3K p110γ inhibitor; IC50 values for inhibition of human recombinant PI3Kγ, α, β, and δ are 30, 940, 20,000, and 20,000 nM respectively.
References:
V Pomel et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase γ. J. Med. Chem. 2006, 49, 3857-3871.
T Rückle et al. PI3Kγ inhibition: Towards an 'aspirin of the 21st century'?. Nature Reviews Drug Discovery 2006, 5, 903-918.
BT Hennessy et al. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nature Reviews Drug Discovery 2005,4,988-1004.
AM Condliffe et al. Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 2005, 106, 1432-1440.
Chemical Name:5-[1-[5-(4-Fluoro-2-hydroxy-phenyl)-furan-2-yl]-meth-(Z)-ylidene]-thiazolidine-2,4-dione
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