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KW 6002  - Istradefylline

CAS 155270-99-8

C20H24N4O4  MW 384.44

Purity: 99 %

Ordering Information:

Cat. No. Axon 1423    Prime Source

Qty1: 5 mg (research sample) / €125  $163

Promotion: 2 x 5 mg @ €180  $234

Qty2: 25 mg (research sample) / €375  $488

Promotion: 2 x 25 mg @ €560  $728

Qty3: on request

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Biological Activity:   Very potent, selective and orally active adenosine A2A receptor antagonist in experimental models of Parkinson's disease   References:   S Shiozaki et al. Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP. Psychopharmacology (Berl). 1999, 147(1), 90-95. [abstract]   TN Chase et al. Translating A2A antagonist KW6002 from animal models to parkinsonian patients. Neurology 2003, 61(11 Suppl 6), S107-11. [abstrat]   PA LeWitt et al. Adenosine A2A receptor antagonist istradefylline (KW-6002) reduces "off" time in Parkinson's disease: a double-blind, randomized, multicenter clinical trial (6002-US-005). Ann. Neurol. 2008, 63(3), 295-302. [abstrat]     Chemical Name: (E)-1,3-diethyl-8-(3,4-dimethoxystyryl)-7-methyl-3,7-dhydro- 1H-purine-2,6- dione

KW 6002 | A2A antagonist | Axon Medchem | Axon 1423 | KW6002 - Istradefylline

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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Axon Adenosine Receptor (AR) Ligands: e.g.

KW 6002 | A2A antagonist

SCH 442416 | A2A antagonist

SCH 58261 | A2A antagonist

CGS 21680 | A2A agonist

UK 432097 | A2A agonist

ADAC | A1 agonist

2-Chloroadenosine | A1/2A ago.

GR 79236 | A1 agonist

SDZ WAG 994 | A1 agonist

Rolofylline | A1 antagonist