Axon Ligands (TM) - alphabetic: [A] [B] [C] [D] [E] [F] [G] [H] [I] [J] [K] [L] [M] [N] [O] [P] [Q] [R] [S] [T] [U] [V] [W] [X] [Y] [Z]

TP-003  - TP003

CAS 628690-75-5

 C23H16F3N3O  MW 407.40

Purity: 99%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1422       Exclusive

Qty1: 2 mg / €105  $137      

Qty2: 5 mg / €155  $202

Qty2: 25 mg / €620  $806

Qty3: on request

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Biological Activity:   Subtype selective partial agonist at GABAA receptor, showing significant efficacy at α3; nonbenzodiazepine anxiolytic   References: online 1   R Dias et al. Evidence for a Significant Role of α3-Containing GABAA Receptors in Mediating the Anxiolytic Effects of Benzodiazepines. J. Neurosci. 2005, 25(46), 10682–10688.   RL Fradley et al. Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands. J. Psychopharmacol. 2007, 4, 384-391. [abstract]   W Sieghart. GABAA receptors as targets for different classes of drugs. Drugs Fut. 2006, 31(8), 685. [abstract]   J Knabl etal. Reversal of pathological pain through specific spinal GABAA receptor subtypes. Nature 2008, 451, 330-334. [abstract] [f1000medicine]     Chemical Name: 4,2'-Difluoro-5'-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]pyridin-3-yl]biphenyl-2-carbonitrile

TP-003 | GABAA α3 agonist | Axon Medchem | Axon 1422 | TP003

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research and synthesis.

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Axon Ligands In The Field:

CP 615003 | GABAA agonist

L-838417 | GABAA agonist

Pagoclone | GABAA α2/3 agonist

SL 651498 | GABAA agonist  

TP-003 | GABAA α3 agonist

GS 39783 | GABAB PAM