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A 83-01

CAS 909910-43-6

C25H19N5S  MW 421.52

Purity: 99%

Soluble in DMSO to 40 mM 

Ordering Information:

Cat. No. Axon 1421    Prime Source Promotion

Qty1:  5 mg / €95  $124

Promotion: 2 x 5 mg @ €140  $182

Qty2: 25 mg / €335  $436

Promotion: 2 x 25 mg @ €500  $650

Qty3: on request

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Biological Activity:   Potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 and its relatives ALK4 and ALK7 (IC50 to be 12, 45 and 7.5 nM respectively). A-83-01 inhibits smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β, but had no effect on BMP signaling; Used to generate rat and human iPS cells towards a mouse ES cell like self-renewal state.   References:   M Tojo et al. The ALK5 inhibitor A-83-01 inhibits smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β. Cancer. Sci. 2005, 96, 791-800. [online]   W Li ... and S Ding et al. Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell 2009, 4, 16-19. [online]     Chemical Name: 3-(6-Methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide

A 83-01 | ALK5 inhibitor | Axon Medchem | Axon 1421 | A83-01

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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