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GW 786034 - Pazopanib hydrochloride

CAS 635702-64-6

C21H23N7O2S.HCl  MW 473.98

Purity: 99%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1420          

Qty1: 5 mg (research sample) / €95  $124

Promotion: 2 x 5 mg @ €130  $169

Qty2: 25 mg (research sample) / €285  $371

Promotion: 2 x 25 mg @ €400  $520

Qty3: on request

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Biological Activity:   A potent and selective inhibitor of tyrosine kinases, targeting VEGFR/c-KIT/PDGFR, blocking angiogenesis; as an oral antineoplastic agent.   References: online 1, 2, 3   G Sonpavde et al. Pazopanib, a potent orally administered small-molecule multitargeted tyrosine kinase inhibitor for renal cell carcinoma. Exp. Opin. Invest. Drugs. 2008, 17(2), 253-261.   G Sonpavde and TE Hutson. Pazopanib: a novel multitargeted tyrosine kinase inhibitor. Curr. Oncol. Rep. 2007, 9(2), 115-9.   K Podar et al. The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma. Proc. Natl. Acad. Sci. USA. 2006, 103(51), 19478-19483.     Chemical Name: 5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide hydrochloride

GW 786034 - Pazopanib | VEGFR/KIT/PDGFR inhibitor | Axon Medchem | Axon 1420 | GW786034

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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