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NVP-TAE684 - TAE 684

CAS 761439-42-3

C30H40ClN7O3S  MW 614.22

Purity: 99%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1416       Prime Source

Qty1: 2 mg (research sample) / €95  $124

Qty2: 5 mg (research sample) / €135  $176

Promotion: 2 x 5 mg @ €200  $260

Qty3: 25 mg (research sample) / €475  $618

Promotion: 2 x 25 mg @ €720  $936

Qty4: on request

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Biological Activity:   Potent, selective and efficacious inhibitor of NPM-ALK.   References: online 1   AV Galkin et al. Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc. Natl. Acad. Sci. USA 2007, 104 (1), 270-275. [online]   U McDermott et al. Genomic Alterations of Anaplastic Lymphoma Kinase May Sensitize Tumors to Anaplastic Lymphoma Kinase Inhibitors. Cancer Res. 2008, 68(9), 3389-3395. [online]   K van Roosbroeck et al. ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions. Haematologica. 2010, 95, 509-513. [online]       Chemical Name: 5-Chloro-N2-{2-methoxy-4-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-phenyl}-N4-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine

NVP-TAE684 | ALK inhibitor | Axon Medchem | Axon 1416 | TAE 684 supplier

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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