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NVP-TAE684 - TAE 684

 

 

CAS 761439-42-3

C30H40ClN7O3S  MW 614.22

Purity: 99%

Soluble in DMSO

 

 

 

 

 

Ordering Information:

 

Cat. No. Axon 1416       Prime Source

 

Qty1: 2 mg / 85  $111

Qty2: 5 mg / 125  $163

Promotion: 2 x 5 mg @ 180  $234

Qty3: 25 mg / 425  $553

Promotion: 2 x 25 mg @ 640  $832

Qty4: on request

 

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or by fax to: +31-50-3600390.

 

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Biological Activity:

 

Potent, selective and efficacious inhibitor of NPM-ALK.

 

References: online 1         List of Publications Using Axon 1416

 

AV Galkin et al. Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc. Natl. Acad. Sci. USA 2007, 104 (1), 270-275. [online]

 

U McDermott et al. Genomic Alterations of Anaplastic Lymphoma Kinase May Sensitize Tumors to Anaplastic Lymphoma Kinase Inhibitors. Cancer Res. 2008, 68(9), 3389-3395. [online]

 

K van Roosbroeck et al. ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions. Haematologica. 2010, 95, 509-513. [online]

 

 

 

Chemical Name: 5-Chloro-N2-{2-methoxy-4-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-phenyl}-N4-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine

 

NVP-TAE684 | ALK inhibitor | Axon Medchem | Axon 1416 | TAE 684 supplier

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

axonmedchem.com 2014

 

Axon Ligands in the Filed:

 

ASP 3026 | ALK inhibitor

AZD 3463 | ALK/IGF1R inhibitor

CH 5424802 | ALK inhibitor

LDK 378 | ALK inhibitor

TAE 684 | ALK inhibitor 

PF 02341066 | Met/ALK inh.

 

 

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